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  1. The success of first-line antiretroviral therapy can be challenged by the acquisition of primary drug resistance. Here we report a case where baseline genotypic resistance testing detected resistance conferrin...

    Authors: E. Anadol, R. Kaiser, J. Verheyen, E. Schülter, J. Emmelkamp, C. Schwarze-Zander, B. Kupfer, J. C. Wasmuth and J. K. Rockstroh

    Citation: European Journal of Medical Research 2010 15:225

    Content type: Case report

    Published on:

  2. Dual therapy with aspirin and clopidogrel increases the risk of gastrointestinal bleeding. Therefore, co-therapy with a proton pump inhibitor (PPI) is recommended by most guidelines. However, there are warning...

    Authors: S. Kenngott, R. Olze, M. Kollmer, H. Bottheim, A. Laner, E. Holinski-Feder and M. Gross

    Citation: European Journal of Medical Research 2010 15:220

    Content type: Research

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  3. Use of potent antiplatelet drugs requires evaluation of platelet function. While platelet function in elective cases is usually assessed in a central laboratory environment, there is also an urgent need for ra...

    Authors: A. A. Hanke, K. Roberg, E. Monaca, T. Sellmann, C. F. Weber, N. Rahe-Meyer and K. Görlinger

    Citation: European Journal of Medical Research 2010 15:214

    Content type: Research

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  4. Renal impairment is a common complication of multiple myeloma occuring in up to 50% of patients at some stage in their disease. Due to occurrence of cast nephropathies we hypothesized circulatory dysregulation...

    Authors: U. Schiemann, H. C. Kaiser, M. Götzberger, R. Schmidmaier, F. Bantle and C. Straka

    Citation: European Journal of Medical Research 2010 15:210

    Content type: Research

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  5. Bone grafting is a vital component in many surgical procedures to facilitate the repair of bone defects or fusions. Autologous bone has been the gold standard to date in spite of associated donor-site morbidit...

    Authors: P. Jungbluth, M. Hakimi, J. P. Grassmann, J. Schneppendahl, A. Kessner, M. Sager, A. R. Hakimi, J. Becker, J. Windolf and M. Wild

    Citation: European Journal of Medical Research 2010 15:196

    Content type: Research

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  6. There are several well established scores for the assessment of the prognosis of major trauma patients that all have in common that they can be calculated at the earliest during intensive care unit stay. We in...

    Authors: S Huber-Wagner, J. Stegmaier, P. Mathonia, T. Paffrath, E. Euler, W. Mutschler, K. G. Kanz and R. Lefering

    Citation: European Journal of Medical Research 2010 15:185

    Content type: Research

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  7. Squamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm. A slow-growing painless expansive swelling is the common presenting symptom. Histopathologically, SOT can be easily misdiagnos...

    Authors: CH Siar, K Nakano, KH Ng, M Tomida, H Nagatsuka and T Kawakami

    Citation: European Journal of Medical Research 2010 15:180

    Content type: Case report

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  8. The cut-out of the sliding screw is one of the most common complications in the treatment of intertrochanteric fractures. The reasons for the cut-out are: a suboptimal position of the hip-screw in the femoral ...

    Authors: A Paech, E Wilde, AP Schulz, G Heinrichs, R Wendlandt, C Queitsch, B Kienast and Ch Jürgens

    Citation: European Journal of Medical Research 2010 15:174

    Content type: Research

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  9. Liver injury due to trauma is a rare indication for transplantation. The main indications in such cases were uncontrollable bleeding and insufficient hepatic function. Because of poor results, liver transplant...

    Authors: M Heuer, GM Kaiser, S Lendemans, S Vernadakis, JW Treckmann and A Paul

    Citation: European Journal of Medical Research 2010 15:169

    Content type: Research

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  10. The sequences of many genomes are available; therefore, relevant methods are needed for rapid and efficient identification of functional genes. The ability of tumour cells to resist apoptosis induced by antica...

    Authors: M Hassan, C Matuschek, PA Gerber, M Peiper, W Budach and E Bölke

    Citation: European Journal of Medical Research 2010 15:162

    Content type: Review

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  11. To examine the in vivo anti-fibrotic effect of rat soluble transforming growth factor β receptor II (RsTβRII) and IFN-γ fusion protein (RsTβRII-IFN-γ) in rat hepatic fibrosis model.

    Authors: H Yao, J Pan, Y Qian, Z Pei, A Bader, NH Brockmeyer, P Altmeyer and L Zhang

    Citation: European Journal of Medical Research 2010 15:152

    Content type: Research

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  12. Avoiding abacavir in HIV-infected patients tested positive for HLA-B*5701 reduces the risk of abacavir hypersensitivity reaction (ABC-HSR). Our aim was to assess the costs of clinically suspected HSR and to es...

    Authors: E Wolf, M Blankenburg, JR Bogner, W Becker, D Gorriahn, MC Mueller, H Jaeger, R Welte, M Baudewig, R Walli and M Stoll

    Citation: European Journal of Medical Research 2010 15:145

    Content type: Research

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  13. Progressive immunodeficiency associated with HIV-infection leads to a progressive course of liver disease in HIV/HCV-co-infected patients. Highly active antiretroviral therapy (HAART) efficiently restores and ...

    Authors: F Grünhage, J-C Wasmuth, S Herkenrath, N Vidovic, G Goldmann, J Rockstroh, F Lammert, J Oldenburg, T Sauerbruch and U Spengler

    Citation: European Journal of Medical Research 2010 15:139

    Content type: Research

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  14. The purpose of this report is to document a case of unsuspected ameloblastoma involving the right man dibular subpontic region in a 38-year-old Cambodian female patient. This lesion was purportedly preceded by...

    Authors: CH Siar, K Nakano, PI Chelvanayagam, KH Ng, H Nagatsuka and T Kawakami

    Citation: European Journal of Medical Research 2010 15:135

    Content type: Case report

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  15. New modalities like Optical Coherence Tomography (OCT) allow non-invasive examination of the internal structure of biological tissue in vivo. The potential benefits and limitations of this new technology for t...

    Authors: A Karl, H Stepp, E Willmann, A Buchner, Y Hocaoglu, C Stief and S Tritschler

    Citation: European Journal of Medical Research 2010 15:131

    Content type: Research

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  16. Gastro-oesophageal reflux disease (GERD) is a common disorder with consequences for the patient's health-related quality of life (HRQoL). In Germany, few data are available on the impact of GERD on work-relate...

    Authors: M Gross, U Beckenbauer, J Burkowitz, H Walther and B Brueggenjuergen

    Citation: European Journal of Medical Research 2010 15:124

    Content type: Research

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  17. To avoid damage to the ureters during bladder neck preparation in radical prostatectomy for prostate cancer, it may be helpful to insert ureteral stents temporarily or to intravenously administer indigo carmin...

    Authors: B Schlenker, C Gratzke, M Seitz, P von Walter, D Tilki, O Reich, D Zaak, CG Stief and MJ Bader

    Citation: European Journal of Medical Research 2010 15:121

    Content type: Research

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  20. This study was performed to investigate the impact of HAART versus no HAART and nucleoside free versus nucleoside containing HAART on the efficacy and safety of pegylated interferon and ribavirin therapy for t...

    Authors: M Vogel, G Ahlenstiel, B Hintsche, S Fenske, A Trein, T Lutz, D Schürmann, C Stephan, P Khaykin, M Bickel, C Mayr, A Baumgarten, P Buggisch, H Klinker, C John, J Gölz…

    Citation: European Journal of Medical Research 2010 15:102

    Content type: Research

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  21. Efficient recruitment and activation of immuno-competent cells is crucial for an effective immune response to hepatitis C virus (HCV) infection. Chemokines and chemokine receptors have been shown to be critica...

    Authors: Martin Coenen and Jacob Nattermann

    Citation: European Journal of Medical Research 2010 15:97

    Content type: Review

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  22. The overall effect of HAART on the liver is the result of the balance between hepatotoxicity and the consequences of immunoreconstitution on the evolution of HIV-associated liver diseases, particularly viral h...

    Authors: JA Pineda, J Macías, JA Mira, N Merchante, J del Valle and KI Neukam

    Citation: European Journal of Medical Research 2010 15:93

    Content type: Review

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  23. Follow-up of vascular changes in a patient with congenital retinocephalofacial vascular malformation syndrome.

    Authors: D Schmidt, H Agostini and M Schumacher

    Citation: European Journal of Medical Research 2010 15:88

    Content type: Case report

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  24. Plexiform neurofibroma (PN) is a rare benign tumor and a special subtype of neurofibromatosis type 1 (NF1). Though the incidence is low, giant PN of the craniomaxillofacial region could result in severe hemifa...

    Authors: Y Feng, Z Yang, T Chen, Q Wang and W Deng

    Citation: European Journal of Medical Research 2010 15:84

    Content type: Case report

    Published on:

  25. in HIV-infected patients with HCV-related chronic hepatitis, liver impairment and drug toxicity may substantially reduce the number of possible therapeutic options.

    Authors: F Ortu, LE Weimer, M Floridia and PE Manconi

    Citation: European Journal of Medical Research 2010 15:81

    Content type: Review

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  26. Kaposi's sarcoma (KS) is a rare angioproliferative tumor associated with human herpesvirus 8 (HHV-8) infection. Four clinical variants of KS have been described: classic, endemic, iatrogenic and HIV-associated...

    Authors: A Potthoff, NH Brockmeyer, M Stücker, U Wieland and A Kreuter

    Citation: European Journal of Medical Research 2010 15:79

    Content type: Case report

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  27. Several studies have shown persistent neurocognitive impairment in patients with a bipolar affective disorder (BD) even in euthymia as well as in patients with a schizoaffective disorder (SAD). The aim of our ...

    Authors: G Studentkowski, D Scheele, P Calabrese, F Balkau, J Höffler, T Aubel, M-A Edel, G Juckel and H-J Assion

    Citation: European Journal of Medical Research 2010 15:70

    Content type: Research

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  29. Serious thrombembolic events occur in otherwise healthy marathon athletes during competition. We tested the hypothesis that during heavy endurance sports coagulation and platelets are activated depending on th...

    Authors: AA Hanke, A Staib, K Görlinger, M Perrey, D Dirkmann and P Kienbaum

    Citation: European Journal of Medical Research 2010 15:59

    Content type: Research

    Published on:

  30. Although there is a clear trend toward internal fixation for ankle arthrodesis, there is general consensus that external fixation is required for cases of posttraumatic infection. We retrospectively evaluated ...

    Authors: B Kienast, J Kiene, J Gille, R Thietje, U Gerlach and AP Schulz

    Citation: European Journal of Medical Research 2010 15:54

    Content type: Research

    Published on:

  31. Sympathetic stimulation leads to a change in electrical skin impedance. So far it is unclear whether this effect can be used to measure the effects of anaesthetics during general anaesthesia. The aim of this p...

    Authors: M Winterhalter, S Münte, M Gerhard, O Danzeisen, T Jüttner, E Monaca, L Hoy, N Rahe-Meyer and P Kienbaum

    Citation: European Journal of Medical Research 2010 15:47

    Content type: Research

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  32. Previous reports on lymphocyte subpopulations in systemic sclerosis (SSc) are conflicting. Therefore, we aimed to investigate the lymphocyte subsets in SSc patients who were not on immunosuppressive therapy.

    Authors: T Gambichler, C Tigges, B Burkert, S Höxtermann, P Altmeyer and A Kreuter

    Citation: European Journal of Medical Research 2010 15:44

    Content type: Research

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  34. Due to organ shortage, average waiting time for a kidney in Germany is about 4 years after start of dialysis. Number of kidney grafts recovered can only be maintained by accepting older and expanded criteria d...

    Authors: M Heuer, A Zeiger, GM Kaiser, Z Mathé, A Goldenberg, S Sauerland, A Paul and JW Treckmann

    Citation: European Journal of Medical Research 2010 15:31

    Content type: Research

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  35. Postoperative surveillance after curative resection for colorectal cancer has been demostrated to improve survival. It remains unknown however, whether intensified surveillance provides a significant benefit r...

    Authors: T Laubert, FG Bader, E Oevermann, T Jungbluth, L Unger, UJ Roblick, H-P Bruch and L Mirow

    Citation: European Journal of Medical Research 2010 15:25

    Content type: Research

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  37. In patients with multiple myeloma, bendamustine monotherapy is effective as 1st and 2nd line therapy. However, data for patients with advanced multiple myeloma is rare.

    Authors: M Michael, I Bruns, E Bölke, F Zohren, A Czibere, N N Safaian, F Neumann, R Haas, G Kobbe and R Fenk

    Citation: European Journal of Medical Research 2010 15:13

    Content type: Research

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  38. This manuscript is communicated by the German AIDS Society (DAIG) http://​www.​daignet.​de. It summarizes a series of presentations and discussions during a wor...

    Authors: HJ Stellbrink, S Baldus, G Behrens, JR Bogner, T Harrer, C Hoffmann, J van Lunzen, J Münch, P Racz, C Scheller, M Stoll, K Tenner-Racz and J Rockstroh

    Citation: European Journal of Medical Research 2010 15:1

    Content type: Review

    Published on:

  39. Non-invasive breath tests can serve as valuable diagnostic tools in medicine as they can determine particular enzymatic and metabolic functions in vivo. However, methodological pitfalls have limited the actual...

    Authors: JF Lock, P Taheri, S Bauer, HG Holzhütter, M Malinowski, P Neuhaus and M Stockmann

    Citation: European Journal of Medical Research 2009 14:547

    Content type: Research

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  41. Hospitals have a critically important role in the management of mass causality incidents (MCI), yet there is little information to assist emergency planners. A significantly limiting factor of a hospital's cap...

    Authors: S Huber-Wagner, R Lefering, MV Kay, J Stegmaier, PN Khalil, AO Paul, P Biberthaler, W Mutschler and K-G Kanz

    Citation: European Journal of Medical Research 2009 14:532

    Content type: Research

    Published on:

  42. Increased vascular permeability is a characteristic feature of sepsis which, in the past, has been ascribed exclusively to a malfunction of endothelial cells. However, recently it has become evident that the e...

    Authors: KF Hofmann-Kiefer, GI Kemming, D Chappell, M Flondor, H Kisch-Wedel, A Hauser, S Pallivathukal, P Conzen and M Rehm

    Citation: European Journal of Medical Research 2009 14:526

    Content type: Research

    Published on:

  43. Numerous reports have shown the influence of renin, nitric oxide (NO) and the endothelin (ET) systems for regulation of blood pressure and renal function. Furthermore, interactions between these peptides have ...

    Authors: SW Reinhold, DC Uihlein, CA Böger, S Kloiber, K Frölich, T Bergler, B Banas, F Schweda and BK Krämer

    Citation: European Journal of Medical Research 2009 14:520

    Content type: Research

    Published on:

  44. There is an unmet medical need for simplified antiretroviral therapy regimens to improve patient's compliance and quality of life. The purpose of this study was to evaluate the efficacy and safety of a once-da...

    Authors: T Weberschock, P Gholam, E Hueter, K Flux and M Hartmann

    Citation: European Journal of Medical Research 2009 14:516

    Content type: Research

    Published on:

  46. Although the emotion regulatory difficulties in patients with major depressive disorder (MDD) are predicted to associate with impaired cardiovascular autonomic regulation, the changes of cardiac vagal regulati...

    Authors: I Tonhajzerova, I Ondrejka, M Javorka, P Adamik, Z Turianikova, V Kerna, K Javorka and A Calkovska

    Citation: European Journal of Medical Research 2009 14(Suppl 4):280

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 4

  47. The mechanism responsible for the central baroreflex resetting with age are an area of limited knowledge. We previously demonstrated that in subjects aged above 50 the airway resistance did not change in respo...

    Authors: M Tafil-Klawe, JJ Klawe, P Zalewski and A Lewandowski

    Citation: European Journal of Medical Research 2009 14(Suppl 4):241

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 4

  48. Free-circulating DNA is present in minute amounts in plasma of healthy individuals, whereas increased levels are found in a number of malignant pathologies including non-small cell lung cancer (NSCLC). The obj...

    Authors: A Szpechcinski, M Dancewicz, P Kopinski, J Kowalewski and J Chorostowska-Wynimko

    Citation: European Journal of Medical Research 2009 14(Suppl 4):237

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 4

  49. Diffuse alveolar hemorrhage (DAH) is a rare and life-threatening condition characterized by hemoptysis, dyspnoea, alveolar infiltrates on chest radiograph and various degrees of anemia. It may occur either as ...

    Authors: E Kamienska, T Urasinski, A Gawlikowska-Sroka, B Glura and A Pogorzelski

    Citation: European Journal of Medical Research 2009 14(Suppl 4):112

    Content type: Case report

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 4

  50. While adjuvant therapy of early-stage non-small-cell lung cancer (NSCLC) is widely accepted, literature data concerning neoadjuvant treatment provide contradictory results with both improved and unaffected sur...

    Authors: J Chorostowska-Wynimko, J Zaleska, M Chabowski, A Szpechcinski, J Zych, P Rudzinski, R Langfort, T Orlowski and K Roszkowski-Sliz

    Citation: European Journal of Medical Research 2009 14(Suppl 4):42

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 4

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