Articles

Total and antigen-specific Ige levels in umbilical cord blood

The present study was conducted to learn whether the perinatal and environmental factors could influence the total and antigen-specific IgE levels in umbilical cord blood. Retrospective data were obtained from...

Authors: AJ Sybilski, A Doboszynska and B Samolinski

Prediction of atopy in the first year of life using cord blood IgE levels and family history

We assessed correlations of total and specific cord-blood IgE (cIgE) levels with allergic symptoms in the first year of life. cIgE levels were determined by an immunoassay test in full-term neonates. This is a...

Authors: AJ Sybilski, A Doboszynska and B Samolinski

Safety of laboratory analyzers for infection testing - results of the market surveillance by the BfArM until end 2007

The European Directive 98/79/EC on in vitro diagnostic medical devices (IVD) stipulates the marketing and post market surveillance of IVD in the European Economic Area. In cases of issues and field corrective act...

Authors: R Siekmeier, J Halbauer, W Mientus and D Wetzel

Assessment of airway hyperreactivity: comparison of forced spirometry and body plethysmography for methacholine challenge tests

Bronchial challenge tests by inhalation of aerosolized methacholine (MCH) are commonly used in the clinical diagnosis of airway hyperresponsiveness (AHR). While the detection of airway narrowing relies on the ...

Authors: F Nensa, W Marek, E Marek, HJ Smith and M Kohlhäufl

Influence of proinflammatory cytokine gene polymorphism on childhood obesity

Obesity development is a complex process which can be influenced by genetic predisposition modified by environmental factors. Nowadays, the problem of overweight and obesity, including related complications, o...

Authors: K Popko, E Górska, B Pyrzak, A Telmaszczyk-Emmel, A Wisniewska, A Majcher, M Wasik and U Demkow

HIV resistance to raltegravir

Similar to all antiretroviral drugs, failure of raltegravirbased treatment regimens to fully supress HIV replication almost invariably results in emergence of HIV resistance to this new drug. HIV resistance to...

Authors: François Clavel

Raltegravir use in special populations

Raltegravir, the first approved integrase inhibitor, has been shown to be virologically effective in Phase II and Phase III clinical trials in both treatment naïve and triple class resistant patients. It also ...

Authors: Margaret Johnson

HIV/HCV-coinfection: which role can new antiretrovirals such as integrase inhibitors play?

End-stage liver disease has become one of the most frequent causes of death in HIV/HCV-coinfected patients. The role of new antiretrovirals in the progression of liver fibrosis has yet to be defined. However w...

Authors: Martin Vogel and Mark Nelson

The use of integrase inhibitors in treatment-experienced patients

Raltegravir, the first approved HIV-1 integrase inhibitor, is able to block the strand transfer step of the HIV proviral DNA integration process into the cellular host DNA. The selected dosage for the pivotal ...

Authors: Jose M Gatell

Raltegravir in treatment naïve patients

Raltegravir is the first integrase inhibitor approved for the treatment of HIV infection based on the superior efficacy it showed compared to optimized backbone therapy alone in patients harboring multidrug re...

Authors: F Cossarini, A Castagna and A Lazzarin

Drug-drug interactions with raltegravir

To review all currently published drug-drug interaction studies with the HIV-integrase inhibitor raltegravir.

Authors: David M Burger

Raltegravir: molecular basis of its mechanism of action

Integration of the HIV-1 viral DNA generated by reverse transcription of the RNA genome into the host cell chromosomes is a key step of viral replication, catalyzed by the viral integrase. In October 2007, the...

Authors: Jean-François Mouscadet and Luba Tchertanov

Integrase inhibitors: Why do we need a new drug class for HIV therapy?

Authors: Jürgen Kurt Rockstroh

Hospital treatment -is it affordable? A structured cost analysis of vaginal deliveries and planned caesarean sections

The analysis of cost effectiveness in hospitals is as difficult as treating the patients properly. We are yet not able to answer the simple question of what costs are caused by a certain diagnosis and its trea...

Authors: IM Heer, S Kahlert, S Rummel, C Kümper, W Jonat and A Strauss

Therapy for nifedipine-induced gingival overgrowth by saireito in rats

A calcium antagonist, nifedipine, causes gingival overgrowth as a side effect. It has been confirmed that the Japanese traditional medicine, Saireito, inhibits the nifedipine-induced proliferation of gingival ...

Authors: T Hattori, K Nakano, T Kawakami, A Tamura, T Ara and PL Wang

Diffuse postoperative peritonitis -value of diagnostic parameters and impact of early indication for relaparotomy

Current criteria for performing relaparotomy for suspected peritonitis are non explicit and based on non-quantitative, subjective arguments or hospital practice. The aim of this study was to determine the valu...

Authors: FG Bader, M Schröder, P Kujath, E Muhl, H-P Bruch and C Eckmann

Perioperative search for circulating tumor cells in patients undergoing radical cystectomy for bladder cancer

Despite having an organ confined tumor stage at the time of radical cystectomy, a certain number of bladder cancer patients will develop local or distant metastases over time. Currently there are no reliable s...

Authors: A Karl, S Tritschler, S Hofmann, CG Stief and C Schindlbeck

Correlation of cutaneous tension distribution and tissue oxygenation with acute external tissue expansion

Today, the biomechanical fundamentals of skin expansion are based on viscoelastic models of the skin. Although many studies have been conducted in vitro, analyses performed in vivo are rare. Here, we present i...

Authors: C Marquardt, E Bölke, PA Gerber, G Kukova, M Peiper, E Rusnak, K Orth and W Fleischmann

German-austrian recommendations for HIV1-therapy in pregnancy and in HIV1-exposed newborn - update 2008

German-Austrian recommendations for HIV1-therapy in pregnancy - Update 2008 Bernd Buchholz (University Medical Centre Mannheim, Pediatric Clinic), Matthias Beichert (Mannheim, Gynecology and Obstetrics Practic...

Authors: Bernd Buchholz, Matthias Beichert, Ulrich Marcus, Thomas Grubert, Andrea Gingelmaier, Annette Haberl and Brigitte Schmied

20^th European Students' Conference. Promising medical scientists willing to look beyond

Authors:

The use of chicken legs for teaching wound closure skills

Training models are required to impart surgical skills, like wound closure techniques, prior to practice in patients. In an ideal case, the tissue characteristics of the model are close to those of humans, eas...

Authors: PN Khalil, M Siebeck, W Mutschler and K-G Kanz

Detection of promoter hypermethylation of the CpG island of E-cadherin in gastric cardiac adenocarcinoma

Abnormal hypermethylation of CpG islands associated with tumor suppressor genes can lead to transcriptional silencing in neoplasia. The aim of this study was to investigate the promoter methylation and express...

Authors: W Guo, Z Dong, Y Guo, G Kuang, Z Yang and Z Chen

Banding pattern indicative of echinococcosis in a commercial cysticercosis western blot

A commercial cysticercosis Western blot was evaluated for serological cross-reactivity of sera from patients with alveolar (AE) and cystic echinococcosis (CE).

Authors: D Tappe, B Grüner, P Kern and M Frosch

Reliability of limb alignment measurement for high tibial osteotomy with a navigation system

High tibial osteotomy (HTO) is one treatment option for young and active patients with unicompartmental osteoarthritis. The success of this procedure substantially depends on the degree of correction of the me...

Authors: J Lützner, AF Groß, KP Günther and S Kirschner

Thoracic outlet syndrome: do we have clinical tests as predictors for the outcome after surgery?

Thoracic outlet syndrome (TOS) is a clinical phenomenon resulting from compression of the neurovascular structures at the superior aperture of the thorax which presents with varying symptoms. Regarding to the ...

Authors: M Sadeghi-Azandaryani, D Bürklein, A Ozimek, C Geiger, N Mendl, B Steckmeier and J Heyn

Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension

Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women,...

Authors: Lori Sweeney and Norbert F Voelkel

Gene expression of circulating tumour cells in breast cancer patients

The diagnostic tools to predict the prognosis in patients suffering from breast cancer (BC) need further improvements. New technological achievements like the gene profiling of circulating tumour cells (CTC) c...

Authors: E Bölke, K Orth, PA Gerber, G Lammering, R Mota, M Peiper, C Matuschek, W Budach, E Rusnak, S Shaikh, B Dogan, HB Prisack and H Bojar

Epidemiological composition, clinical and treatment characteristics of the patient cohort of the german competence network for HIV/AIDS

As its central basis for research, the Competence Network for HIV/AIDS (KompNet) established a nationwide cohort study on HIV-positive patients being in medical care in Germany. In this paper, we describe the ...

Authors: K Jansen, NH Brockmeyer, M Hahn, I Kaul, S Fenske, M Rausch, B Kuhlmann, A Ulmer, E Lauenroth-Mai, T Harrer, M Hower, A Skaletz-Rorowski and C Michalik

Gene expression of circulating tumour cells and its correlation with tumour stage in breast cancer patients

Breast cancer (BC) represents one of the leading causes of cancer related deaths worldwide. New tools for diagnostic staging and therapeutic monitoring are needed to improve individualized therapies and improv...

Authors: E Bölke, K Orth, PA Gerber, G Lammering, R Mota, M Peiper, C Matuschek, W Budach, E Rusnak, S Shaikh, B Dogan, HB Prisack and H Bojar

Gasperini syndrome as clinical manifestation of pontine demyelination

The Gasperini syndrome is a very rare brainstem disease characterized by the typical combination of ipsilateral lesions of the cranial nerves V-VII and dissociated contralateral hemihypesthesia, whereas both c...

Authors: M Krasnianski, T Müller, S Zierz and M Winterholler

Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial

The aim of this trial was to assess the relative efficacy of a sage/echinacea spray and a chlorhexidine/lidocaine spray in the treatment of acute sore throats.

Authors: A Schapowal, D Berger, P Klein and A Suter

Effects of exercise training on mobilization and functional activity of blood-derived progenitor cells in patients with acute myocardial infarction

The aim of the present study was to determine whether regular exercise training (ET) is effective at promoting the mobilization of CPCs and improving their functional activity in patients with recently acquire...

Authors: M Brehm, F Picard, P Ebner, G Turan, E Bölke, M Köstering, P Schüller, T Fleissner, D Ilousis, K Augusta, M Peiper, Ch Schannwell and BE Strauer

Idiopathic Recurrent Calcium Urolithiasis (IRCU): variation of fasting urinary protein is a window to pathophysiology or simple consequence of renal stones in situ? A tripartite study in male patients providing insight into oxidative metabolism as possible driving force towards alteration of urine composition, calcium salt crystallization and stone formation*

In IRCU it is uncertain whether variation of urinary protein, especially non-albumin protein (NAlb-P), is due to the presence of stones or reflects alteration of oxidative metabolism.

Authors: PO Schwille, A Schmiedl and J Wipplinger

Evaluation of quantitative liver function tests in HIV-positive patients under anti-retroviral therapy

Quantitative tests of liver function (QTLF) which are based on the hepatic metabolism or clearance of test substances have been successfully used to predict prognosis of a variety of different liver diseases. ...

Authors: M Miller, A Kahraman, B Ross, M Beste and G Gerken

Maintenance electroconvulsive therapy for comorbid pharmacotherapy-refractory obsessive-compulsive and schizoaffective disorder

There is a high comorbidity of schizophrenia and obsessive-compulsory disorder (OCD) associated with more severe symptoms. Standard pharmacotherapy achieve symptom improvement in approximately 60% only.

Authors: F Hanisch, J Friedemann, J Piro and P Gutmann

Mycophenolate mofetil as second line immunosuppressant in myasthenia gravis - a long-term prospective open-label study

The preferred immunosuppressive drug for long term treatment of myasthenia gravis (MG) is azathioprine (AZA). Mycophenolate mofetil (MMF) was suggested as an effective and safe second line alternative to AZA.

Authors: F Hanisch, M Wendt and S Zierz

A phase II study on safety and efficacy of high-dose N-acetylcysteine in patients with cystic fibrosis

We conducted a single-centre, randomised, double-blinded, placebo-controlled phase II clinical study to test safety and efficacy of a 12-week therapy with low-dose (700 mg/daily) or high-dose (2800 mg/daily) o...

Authors: N Dauletbaev, P Fischer, B Aulbach, J Gross, W Kusche, U Thyroff-Friesinger, TOF Wagner and J Bargon

The time of diagnosis impacts surgical management but not the outcome of patients with gallbladder Carcinoma

Only 50% of gallbladder cancers (GBC) are recognized before operation and the remaining tumors are diagnosed during surgery or afterwards by the pathologist. These situations may demand substantial modificatio...

Authors: F Löhe, G Meimarakis, C Schauer, M Angele, KW Jauch and RJ Schauer

The patient cohort of the German competence network for HIV/AIDS (KompNet):a profile

In this paper, we describe the main objectives, the study design and the onset of the patient cohort of the German Competence Network for HIV/AIDS (KompNet). Furthermore, we depict sociodemographic and clinica...

Authors: K Jansen, C Michalik, M Hahn, S Dupke, S Esser, H Jaeger, S Köppe, A Moll, A Plettenberg, RE Schmidt, A Skaletz-Rorowski and NH Brockmeyer

Conservative management of rectal perforation after nerve sparing endoscopic extraperitoneal radical prostatectomy (NS EERPE) in a patient with a past history of polypectomy

Rectal polypectomy causes thinning (or even perforation) of the rectal wall in addition to thermic injury at the polypectomy site.

Authors: WY Khoder, AJ Becker, B Schlenker, S Tritschler, PJ Bastian and CG Stief

Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions

Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dys...

Authors: CH Siar, VPA Oo, H Nagatsuka, K Nakano, KH Ng and T Kawakami

Macrolide antibiotics like azithromycin increase lipopolysaccharide-induced IL-8 production by human gingival fibroblasts

Macrolide antibiotics are reported to modulate the production of cytokines in various type of cells. We examined the effect of macrolide antibiotics on inflammatory cytokines (IL-6 and IL-8) and chemical media...

Authors: A Kamemoto, T Ara, T Hattori, Y Fujinami, Y Imamura and P-L Wang

Airway surface liquid contains endogenous DNase activity which can be activated by exogenous magnesium

The removal of highly viscous mucus from the airways is an important task in the treatment of chronic lung disease like in cystic fibrosis. The inhalation of recombinant human DNase-I (rhDNase-I) is used to fa...

Authors: J Rosenecker, S Naundorf and C Rudolph

Antihypertensive efficacy of metoprolol XL/Low dose chlorthalidone (6.25 mg) combination: a randomized, comparative study in Indian patients with mild-to-moderate essential hypertension

High blood pressure is one of the most important risk factors, directly responsible for increasing the cardiovascular morbidity and mortality. The primary objective was to evaluate the efficacy of metoprolol X...

Authors: A Pareek, SD Zawar, SB Salagre, NB Chandurkar and ND Karnik

Perioperative blood loss in open retropubic radical prostatectomy - is it safe to get operated at an educational hospital?

Blood loss during radical prostatectomy has been a long term issue. The aim of this study was to investigate the influence of the training level of the first assistant regarding blood loss in open retropubic r...

Authors: A Karl, A Buchner, H Beckerv, M Staehler, M Seitz and C Stief

Very early posttraumatic serum alterations are significantly associated to initial massive RBC substitution, injury severity, multiple organ failure and adverse clinical outcome in multiple injured patients

Multiple severe trauma frequently leads to massive dysbalances of the human immune system. This phenomenon is known as "Systemic Inflammatory Response Syndrome (SIRS)". SIRS is connected to multiple organ failure...

Authors: V Bogner, L Keil, K-G Kanz, C Kirchhoff, BA Leidel, W Mutschler and P Biberthaler

Treatment during primary HIV infection does not lower viral set point but improves CD4 lymphocytes in an observational cohort

To investigate if early treatment of primary HIV-1 infection (PHI) reduces viral set point and/or increases CD4 lymphocytes.

Authors: C Koegl, E Wolf, N Hanhoff, H Jessen, K Schewe, M Rausch, J Goelz, A Goetzenich, H Knechten and H Jaeger

1. Deutsch-Österreichisch-Schweizerischer AIDS-Kongress (SÖDAK 2009)

Authors:

Acoustic monitoring (RFM) of total hip arthroplasty results of a cadaver study

At present there are no reliable non-traumatic and non-invasive methods to analyse the healing process and loosening status after total hip replacement. Therefore early as well as late loosening of prosthesis ...

Authors: AC Unger, H Cabrera-Palacios, AP Schulz, Ch Jürgens and A Paech

Chest wall and intrathoracic desmoid tumors: surgical experience and review of the literature

Desmoid tumors are fibroblastic/myofibroblastic neoplasms, which originate from musculo-aponeurotic structures and are classified as deep fibromatoses. Despite their benign histologic appearance and lack of me...

Authors: E Bölke, H Krasniqi, G Lammering, R Engers, C Matuschek, S Gripp, PA Gerber, G Fischer, M Peiper, S Shaikh, W Budach and K Orth